GOMEZ, Francisco Javier; ARANGO, Pedro; RUIZ, Jorge Andrés    FERNANDEZ, Juan Manuel. Realización de un procedimiento con anestesia total intravenosa ordenada por computador, utilizando un programa diseñado en la Universidad de Antioquia. []. , 36, 3, pp.173-177. ISSN 0120-3347.

An infusión controlled by a target concentratiuon is a system guided by a computer that allows the administration of pharmachologycal drugs in Duch way that a defined concentration is reached and maintained in a tissue compartment; generally, plasma or the brain, based on a pharmachodynamic and pharmacokinetic model. In this article, the case of a patient to whom total intravenous anesthesia was applied, controlled by target concentration in effective site, using a program developed together by the anesthesiology department and the bioengineering program of the Universidad de Antioquia is presented. After being validated with other similar programs like the Standpump, a clinical test was made. The results were satisfactory and the adequate anesthesia depths were reached for the surgical procedure, in accordance with the concentrations in the effective site reported worldwide. Additionally, the homodynamic behavior of the patient was stable and his recovery was satisfactory as well.

: Propofol; pharmacokinetic; pharmachodynamica; total intravenous ; anesthesia.