MARTIN, Lynn D.. The basic principies of anesthesia for the neonate. []. , 45, 1, pp.54-61. ISSN 0120-3347.

Introduction: There are significant developmental differences in physiology and pharmacology in neonates that make the conduct of a safe anesthetic much more challenging in a neonate. Objectives: Complete a focused review of the current knowledge of the physiological and pharmacologic differences seen in newborns that impact the safe administration of anesthesia. Methods: A selective review of literature in developmental changes in physiology and pharmacology was completed. Results: This knowledge acquired in the review was used to establish common principles for the safe administration of anesthesia to newborn patients. Conclusion: In spite of the persistence of large gaps in our knowledge in this physiology and pharmacology, common modern anesthetic management principles for neonatal surgery have significantly improved clinical outcomes.

: Infant newborn; Anesthesia general; Pharmacology; Anesthesia conduction; Pharmacokinetics.

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