Revista de la Academia Colombiana de Ciencias Exactas, Físicas y Naturales
ISSN 0370-3908
CASTILLO, John J.; ORDUZ, Angie E. ROZO, Ciro E.. Characterization of the non-covalent conjugate grapheme folic acid using Raman spectroscopy and computational methods. []. , 42, 162, pp.96-103. ISSN 0370-3908. https://doi.org/10.18257/raccefyn.524.
Hybrid compounds formed by biomolecules and nanometric structures are attracting interest for the development of applications in the fields of biosensors and drug delivery. In this study we prepared a grapheme-folic acid conjugate which we characterized by Raman spectroscopy and the density functional theory (DFT) computational method. The non-covalent conjugate was performed through a simple and fast one-pot method. The analysis of ratio intensity of D and G bands in the Raman spectroscopy evidenced graphene functionalization. The DFT method showed that the bond between graphene and folic acid occurs by non-covalent π-π and hydrogen bond interactions. Graphene and folic acid conjugates will allow the design of biosensors for the detection of cancer cells overexpressing folate receptors using analytic devices for a faster, more effective and timely diagnosis of cancer.
: Graphene; Raman spectroscopy; Folic acid; Computational methods.