RODRIGUEZ, Astrid Jannet et al. POSSIBLE IMPLICATION OF THE RNASEH1 GENE IN THE ETIOLOGY OF TYPE 1 DIABETES MELLITUS. []. , 8, 1, pp.143-152. ISSN 1657-9550.

Complex disorders are characterized by presenting many genes and other environmental factors implicated in their etiology. The genetic bases of type 1 diabetes mellitus (T1D) suppose a major effect of the HLA complex which interacts with other genes and the environment. Much has been written about the possible implication of viral infections as triggers of T1D. This review explores the mechanisms by which the RNASEH1 gene could be involved in the etiology of T1D, due to a viral infection. The RNASEH1 gene is located in chromosome 2p25, which has been recently implicated in the susceptibility to T1D by the authors, through genetic analysis. This text hopes to establish a biological context for the genetic data. Taking into account that this is a multifactorial disease, this approach does not exclude the eventual participation of other genes or environmental factors.

: type 1 diabetes; genetic susceptibility; RNASEH1 gene; environmental factors.

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