PERTUZ M, Yolima; GONZALEZ R, Gisela    ACOSTA M, Shirley. USE OF INFLAMMATION OR INFECTION BIOMARKERS IN SEPSIS DIAGNOSIS IN INTENSIVE CARE UNITS IN SANTA MARTA, COLOMBIA. []. , 15, 2, pp.28-36. ISSN 1657-9550.  https://doi.org/10.17151/biosa.2016.15.2.4.

Objective: To evaluate the diagnostic ability of presepsin, procalcitonin and C-reactive protein (CRP) biomarkers in septic patients in intensive care units in Santa Marta (Colombia). Materials and Methods: Case-control studies, biomarker determination, was made by analytical methods. The discriminant ability of different markers was valued by using the area under the ROC curve. Results: Of the patients diagnosed with sepsis, 55% had negative blood cultures, and 45% were positive. In this study the area under the curve (AUC) for presepsin was 0.996; for procalcitonin was 0.709, and for CPR was 0.607. With a significance level of 0.05, presepsin showed a p-value of 0.006; procalcitonin showed a value of 0.084 and C-reactive protein showed a value of 0.23. Conclusions: It was determined that presepsin is the best biomarker for early diagnosis of sepsis.

: sepsis; biomarkers; presepsin; diagnosis; prognosis.

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