Abstract

VIVAS, Carlos Arturo. Polycystic ovarian syndrome, endometrium and abortion risk. Rev Colomb Obstet Ginecol [online]. 2005, vol.56, n.4, pp.303-309. ISSN 0034-7434.

Polycystic ovarian syndrome is the most frequent endocrinopathy in reproductive age women (5-7%). The diagnosis is made when two out of three components are present, such as hyperandrogenism, polycystic ovaries and oligoovulation. These women have high levels of luteinizing hormone (LH), hyperisulinemia and hyperandrogenism and an increased rate of abortion has been reported in these patients. This fact could be related to changes found in the endometrium and the elevated serum levels of androgens and insulin. These changes can lead to an inadequate implantation and probably to an increase in first trimester pregnancy losses. Therapeutic approaches such as the use of insulin-sensitizing drugs to decrease insulin levels could be useful in decreasing abortion rates in these patients.

Keywords : polycystic ovarian syndrome; endometrium; abortion; insulin.

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