Services on Demand
Journal
Article
Indicators
Cited by SciELO
Access statistics
Related links
Cited by Google
Similars in SciELO
Similars in Google
Share
Revista Colombiana de Cardiología
Print version ISSN 0120-5633
Abstract
RUBIO, Carlos M et al. Incidence, risk factors and prognosis of cardiac allograft vasculopathy in colombian patients according to the classification of the ISHLT (International Society of Heart and Lung Transplantation). Rev. Colomb. Cardiol. [online]. 2013, vol.20, n.2, pp.104-110. ISSN 0120-5633.
Objective: to describe the incidence and prognosis of cardiac allograft vasculopathy (CAV: cardiac allograft vasculopathy) according to the classification proposed by the International Society for Heart and Lung Transplantation (ISHLT). Methodology: cohort study of heart transplant recipients conducted between February 2003 and November 2011 with angiographic follow-up. The primary outcome was CAV according to the ISHLT. We used chi-square tests for categorical variables and Student t test for quantitative variables. Kaplan-Meier survival analysis was made. Results: 118 patients were included. 83.1% were male with a mean age of 46.4 IQR (38.4 to 55.6) years. The average follow-up was 5 + 4.7 years with 2.4 + 1.6 coronary angiograms / patient. The overall incidence of CAV was 23.7%. Grade 1 (mild) 11.9%, grade 2 (moderate) 7.6% and grade 3 (severe) 4.2%. The only factor with a modest association was pulmonary hypertension with RR 2.54 (1.1 to 6.1) p = 0.05. The mortality of patients according to the degree of vasculopathy was: mild 0%, grade 2 (moderate) 42% RR 2.59 CI 95% (1.14 to 5.9) p = 0.024; Grade 3 (severe) 72 % RR 4.44 95% CI (2.27 to 8.6) p <0.0005. Conclusions: the incidence of CAV was 23.7%. The only factor modestly related was pulmonary hypertension. The scale proposed by the ISHLT is associated in grades 2 and 3 (moderate and severe) with significant mortality.
Keywords : vasculature; vessels; heart transplant; rejection; coronary angiography.