Abstract

OSMA CH, Handerson Rafael et al. Metastatic anal canal squamous cell carcinoma in a patient with HIV treated with concomitant radiotherapy chemo. Case report and literature review. Rev Col Gastroenterol [online]. 2019, vol.34, n.4, pp.438-444. ISSN 0120-9957.  https://doi.org/10.22516/25007440.290.

Anal canal carcinoma is responsible for up to 4% of all cases of colon, rectum and anus cancer. The most common histological type is squamous cell carcinoma. A non-negligible proportion of patients have metastasized by the time of diagnosis. In these stages the prognosis is poor, and treatment is usually based on palliative chemotherapy with cisplatin and 5-fluorouracil. Five year survival rates do not exceed 30%. Some recent studies have suggested that multidisciplinary chemoradiotherapy (chemotherapy combined with radiation therapy) in earlier stages of the disease could improve survival for a select group of patients.

We present the case of a 54-year-old male patient with squamous cell carcinoma of the anal canal with extensive metastasis who also had HIV. He was treated at an institution specializing in cancer treatment where complete remission of the disease was achieved after treatment with chemoradiotherapy with Mitomycin C and 5-fluorouracil. He remains in remission four years after discontinuation of treatment. We discuss the case and review the literature.

Keywords : Anal canal; neoplasms of the anus; squamous cell carcinoma; HIV; chemoradiotherapy.

        · abstract in Spanish     · text in English | Spanish     · English ( pdf ) | Spanish ( pdf )