Abstract

MONTOYA VILLEGAS, JULIO CÉSAR; PENA GONZALEZ, ÁNGELA; SATIZABAL SOTO, JOSÉ MARÍA  and  GARCIAVALLEJO, FELIPE. IN SILICO SYSTEMIC ANALYSIS OF THE DIFFERENTIAL EXPRESSION OF GENES LOCALIZED IN THE DOWN SYNDROME CRITICAL REGION (DSCR) IN NORMAL HUMAN BRAIN. rev.fac.med [online]. 2012, vol.20, n.1, pp.15-26. ISSN 0121-5256.

One of the most important challenges of the 21st Century Neurology is to build gene expression profiles along the different structures of human brain trying to correlate them with some neuropathologies. The expression profiles of eight HAS21 genes located on the Down syndrome critical region in different structures of the normal human brain was analyzed. From DNA microarray experiments of normal human brains which are available in the free access human brain database of the Brain Atlas project of the Allen Institute for Brain Sciences in Seattle, Washington (http://www.brainmap.org) expression levels data of eight HSA21/DSCR genes along different structures of normal human brain were statistically analyzed. A differential expression of these genes HSA21/DSCR in some anatomic structures located in the frontal lobe, limbic lobe and cerebral central nuclei was registered. Putamen, caudate nucleus, parahipocampal gyro and central areas, showed high levels of transcription for those HSA21/DSCR genes included in the study; these areas of the brain appear to be associated with some processes of learning and memory. This study allowed us to correlate the differential transcription of DSCR genes, their structural localization and functional role in brain function.

Keywords : DNA microarray analysis; gene expression profiling; computational biology; brain; Down Syndrome.

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