Abstract

BASTIDAS GOYES, Alirio Rodrigo; MORA, Claudia; ARSANIOS, Daniel Martin  and  ORDUZ, Keisy. Systemic lupus erythematosus, a disease conditioned by the environment. Rev.Colomb.Reumatol. [online]. 2021, vol.28, suppl.1, pp.12-20.  Epub Feb 13, 2021. ISSN 0121-8123.  https://doi.org/10.1016/j.rcreu.2021.03.003.

Systemic lupus erythematosus is an autoimmune disease that involves several systems, affects mainly young adult women, and causes a significant deterioration in quality of life. Different environmental aspects are known to facilitate the development of lupus in predisposed individuals. For several years it has been known that factors such as exposure to UV rays are related to the development of lupus; however, due to factors inherent to globalization, life-style changes, improved knowledge of cell signaling pathways as well as a better understanding of metabolomics, proteomics an genomics, it has been possible to better understand the relationship between cells and their environment. This study based on a narrative review, compiles the existing evidence on different risk factors and the development of lupus, including aspects typical of the Colombian population.

Keywords : Systemic lupus erythematosus; Environmental exposure; Epigenetic changes; Latin America; Colombia.

        · abstract in Spanish     · text in English     · English ( pdf )