Services on Demand
Journal
Article
Indicators
Cited by SciELO
Access statistics
Related links
Cited by Google
Similars in SciELO
Similars in Google
Share
Revista Colombiana de Reumatología
Print version ISSN 0121-8123
Abstract
ULHAQ, Zulvikar Syambani et al. MicroRNA-146a and its target gene IRAK1 polymorphisms confer susceptibility to systemic lupus erythematosus. Rev.Colomb.Reumatol. [online]. 2021, vol.28, suppl.2, pp.116-122. Epub May 04, 2024. ISSN 0121-8123. https://doi.org/10.1016/j.rcreu.2021.05.007.
Objective:
To clarify the association between miR-146a, miR-499, and IRAK1 polymorphism and systemic lupus erythematosus (SLE) predisposition.
Methods:
A literature search was conducted until 12 September 2020 in accordance with the PRISMA guidelines. The keywords "miRNA-146a", "miRNA-499", "IRAK1" and "SLE" were used in combination to obtain case-control studies evaluating the abovementioned gene polymorphism and the risk of SLE.
Results:
Patients harbouring C allele of miRNA-146a rs2431697 exhibited low SLE risk (CC vs. TC + TT, OR = .77, 95% CI = .62-.95, p = .019; TC vs. CC + TT, OR = .84, 95% CI = .71-.98, p = .027; and TC vs. TT, OR = .73, 95% CI = .61-.86, p = .000), whereas patients carrying the A allele and AA genotype of rs3027898 in IRAK1 had significantly decreased SLE susceptibility (A vs. C, OR = .73, 95% CI = .60-.87, p = .001; AA vs. CA + CC, OR = .64, 95% CI = .42-.97, p = .037; AA + CA vs. CC, OR = .71, 95% CI = .56-.88, p = .003, and AA vs. CC, OR = .49, 95% CI = .31-.77, p = .002). No association was observed between miRNA-146a rs2910164 and miRNA-499 rs3746444 with SLE risk.
Conclusion:
This study demonstrates associations between miRNA-146a and IRAK1 polymor phisms with SLE risk. Larger studies on these associations are needed in the future to support our results.
Keywords : miRNA-146a; miRNA-499; IRAK1; Lupus erythematosus Systemic; predisposition; Disease susceptibility.