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Revista Colombiana de Reumatología
Print version ISSN 0121-8123
Abstract
ACOSTA-COLMAN, Isabel et al. Association between vitamin D deficiency and disease activity in Paraguayan patients with systemic lupus erythematosus. Rev.Colomb.Reumatol. [online]. 2022, vol.29, n.1, pp.19-25. Epub Jan 12, 2023. ISSN 0121-8123. https://doi.org/10.1016/j.rcreu.2020.12.010.
Objective:
To identify the association between vitamin D (VD) concentrations and the activity of systemic lupus erythematosus (SLE) and determine a supplementation dose that allows patients to maintain adequate levels of VD.
Methods:
Longitudinal, observational study. Serum levels of 25-hydroxy-VD were measured in 100 Paraguayan SLE patients from the Hospital de Clínicas between 2016 and 2018. To analyze the response to different doses of VD supplementation, 50 patients received 1000IU/day and the other 50 patients received 2000IU. SLE disease activity measured by SELENA-SLEDAIwas scored before and after supplementation.
Results:
The mean age was 27.5 ±9.8 years, 88.9% of patients presented mild disease activ ity and 11.1% presented moderate to severe activity. The mean VD concentration was 30.8 ± 11.8 ng/mL. A total of 34% of patients presented VD insufficiency and 13% VD defi ciency. There was an inverse relationship between VD concentrations and SLE disease activity (p = 0.03). Increasing levels of serum VD are associated with supplementation of 2000 IU/day (p = 0.0224).
Conclusion:
SLE activity was associated with low levels of VD. In our cohort, SLE patients required a supplementation dose equal to or greater than 2000 IU/day to increase their serum VD.
Keywords : Lupus erythematosus; Systemic; Vitamin D; Disease activity.