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Revista Facultad Nacional de Salud Pública
Print version ISSN 0120-386XOn-line version ISSN 2256-3334
Abstract
LESMES-RODRIGUEZ, Lida Carolina; VELANDIA-BOBADILLA, Didier José and JARAMILLO-HERNANDEZ, Dumar Alexander. Seroincidence of Sars-CoV-2 IgG Antibodies and Risk Factors in Asymptomatic Health Care Workers at the Villavicencio Departmental Hospital. Rev. Fac. Nac. Salud Pública [online]. 2022, vol.40, n.2, e03. Epub May 29, 2023. ISSN 0120-386X. https://doi.org/10.17533/udea.rfnsp.e346034.
Objective:
To estimate the cumulative seroincidence of antisars-CoV-2 immunoglobulin (Ig) class G (IgG) in asymptomatic health care workers and its epidemiological association within the functional areas of the Villavicencio Departmental Hospital (HDV).
Methodology:
A longitudinal analytical observational study of a cohort of workers was conducted in which anti- SARS-CoV-2 IgG levels in blood serum were measured every 21 days on three occasions using an indirect ELISA in a random representative sample (n = 105) of hospital health workers (N = 756). The data collection tool was a survey in which each healthcare worker indicated that they had not been diagnosed with COVID-19 and provided information on the independent variables: sex, age, job status, functional area, and comorbidities.
Results:
The baseline prevalence for SARS-CoV-2 among asymptomatic HDV healthcare workers was 9.52% (CI 95% 5.25-16.65). Cumulative seroincidence over 42 days was 12.38% (CI 95% 7.38-20.04). Relative risk (RR) was used to establish the risk factors associated with the independent variables. Male sex (adjusted RR 3.34, CI 95% 1.98-5.86), obesity (adjusted RR 10.98, CI 95% 1.41- 85.98) and female sex (adjusted RR 2.15, CI 95% 1.12-4.31) in the functional areas of Hospitalization, Critical Medicine and Emergency, respectively, are risk factors in the HDV.
Conclusion:
During 42 days of epidemiological follow-up, 13 out of 105 hospital healthcare workers seroconverted positively for SARS-CoV-2 and remained asymptomatic. Additionally, significant risk factors are associated with their exposure to this virus in the HDV.
Keywords : severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2); indirect ELISA; coronavirus disease 2019 (COVID-19); Villavicencio Departmental Hospital; immunoglobulin class G (IgG); pandemic.