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Acta Biológica Colombiana
Print version ISSN 0120-548X
Abstract
PEREZ-QUINTERO, ÁLVARO and LOPEZ, CAMILO. Identification of cisregulatory Elements and Bioinformatic Prediction of Transcriptional Factors Involved in Regulation of miRNAs in Plants. Acta biol.Colomb. [online]. 2013, vol.18, n.1, pp.107-120. ISSN 0120-548X.
MicroRNAs (miRNAs) are a group of small non coding RNAs involved in the control of gene expression through the degradation of mRNAs in a sequence specific manner. miRNAs expression is dependent on RNA polymerase II as most of the coding protein genes. The regulation of miRNAs expression is under the coordinated and combinatorial control of transcription factors (TFs). A bionformatic approach was carried out to identify transcription factor binding sites (TFBS) in the promoter of miRNAs genes in 17 different plant species and the possible involvement of TF in antibacterial response was analyzed. In nine of the plants studied significant differences in TFBS distribution in the promoter of miRNAs were observed when compare to the promoter of protein coding genes. TFBS as CCA1, T-box y SORLREP3 were present on the promoters of the cassava miRNAs induced in response to the infection by the bacteria Xanthomonas axonopodis pv. manihotis. These TFBS are also present in the promoter of genes coding for proteins involved in circadian rhythm and light responses, suggesting a crosstalk between these process and immune plant responses. Taken together, the results here described give insight about the transcriptional mechanisms involved in the expression of miRNAs.
Keywords : gene expression; miRNA; promoter; transcription factor.