Abstract

ARISTIZABAL-HERNANDEZ, JOSÉ JULIÁN et al. Use of N-acetylcysteine in patients with hepatitis by antitubercular agents: systematic review. Salud, Barranquilla [online]. 2023, vol.39, n.3, pp.1017-1033.  Epub May 10, 2024. ISSN 0120-5552.  https://doi.org/10.14482/sun.39.03.005.258.

The aim of this systematic review was to estimate the effectiveness of N-Acetylcysteine in the treatment of hepatotoxicity induced by antitubercular agents, we included randomized clinical trials, there was no language nor publication status restriction, published until December 2021. The searched databases were CENTRAL, CINAHL, LILACS, MEDLINE, Pubmed, Scielo, Scopus y Web of Science; out of 33 articles found, one of them met the inclusion criteria and had low bias risk. The time to biochemical resolution was 7,5 days (IQR 5,511) in the treatment arm, and 8 (IQR 5-13) in the placebo arm. Time of hospital stay was 9 days (IQR 6-15) in the treatment arm, and 18 (IQR 10-25) in the placebo arm. Mortality (14 %) didn't differ between groups. Further clinical trials may be needed to determine the therapeutic role of N-acetylcysteine in patients with drug-induced liver injury caused by antituberculous agents.

Keywords : acetylcysteine; hepatitis; antitubercular agents.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )