Services on Demand
Journal
Article
Indicators
- Cited by SciELO
- Access statistics
Related links
- Cited by Google
- Similars in SciELO
- Similars in Google
Share
Iatreia
Print version ISSN 0121-0793
Abstract
JIMENEZ DEL RIO, Marlene and VELEZ-PARDO, Carlos. Lymphocytes as a cell model to study Alzheimer's and Parkinson's diseases. Iatreia [online]. 2006, vol.19, n.1, pp.47-61. ISSN 0121-0793.
ALZHEIMERS DISEASE (AD) AND PARKINSONS disease (PD) are two common progressive neurodegenerative disorders that affect a large group of individuals in Antioquia, Colombia. Up till now, there is not an effective and definitive therapeutic treatment aimed to reduce or retard the clinic and pathologic symptoms induced by both devastating diseases. Thus, the biochemical mechanism(s) involved in neural loss has mainly been studied in biological models. In this article the authors, based on their own scientific experience and others, have proposed lymphocytes as a cellular model to study the molecular signalling mechanism induced by oxidative stress in AD and PD. Remarkably, lymphocytes and neurons are cellularly and biochemically alike. Indeed, lymphocytes express at least six different biological systems such as catecholaminergic, serotonergic, acetylcholinergic, glutamatergic, noradrenergic and GABAergic systems considered to be exclusively pertain to neural cells!. Given that lymphocytes are post-mitotic cells (i.e. G0 cell cycle) and possess the synthesis, transport and processing systems of amyloid-beta precursor protein (AβPP), presenilins and parkin proteins, these cells constitute not only an ideal bio-model to better understanding of the pathological signalling in those neurodegenerative processes, but also represent a meaningful tool to design innovative and rational therapeutic strategies focussed to arrest the neuronal death in Alzheimers and Parkinsons patients from Antioquia.
Keywords : ALZHEIMER; APOPTOSIS; LYMPHOCYTES; MODEL; OXIDATIVE STRESS; PARKINSON.