Abstract

CASTRO, Luz Ángela; ALVAREZ, María Inés  and  MARTINEZ, Ernesto. Candida in the oral cavity of HIV-infected patients: Identification of species and susceptibility to fluconazole in Cali, Colombia. Iatreia [online]. 2015, vol.28, n.4, pp.368-377. ISSN 0121-0793.  https://doi.org/10.17533/udea.iatreia.v28n4a02.

Introduction: Candida albicans is the most frequently isolated yeast from the oral cavity of HIV-infected individuals. The use of fluconazole has increased the number of resistant or less-sensitive Candida species different from C. albicans, to this antifungal agent. Objective: To establish the Candida species present in the oral cavity of HIV-infected individuals at a hospital in Cali (Colombia), their population densities, and the susceptibility to fluconazole of species different from C. albicans. Materials and methods: Samples were cultured in CHROMagar Candida and the number of colony forming units (CFU) was counted. Yeast identification was done with API 20C Aux, and the susceptibility tests to fluconazole, by Etest. Results: 230 patients were studied, and 202 isolates were obtained: 106 single and 96 mixed. C. albicans predominated, followed by C. dubliniensis and C. glabrata. Candida species other than C. albicans predominated in counts lower than 400 CFU/mL. Susceptibility study to fluconazole of species different from C. albicans showed that 14 (40 %) of the isolates were susceptible dose-dependent and 7 (20 %), resistant. Conclusion: In the studied population, the oral cavity was colonized by non-wild type isolates that represent a risk for the development of oropharyngeal candidiasis resistant to fluconazole treatment.

Keywords : Candida; CD4 Lymphocyte Count; Fluconazole; HIV; Oral cavity.

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