Abstract

RODRIGUEZ, Javier O. NEW DIAGNOSIS AID METHOD WITH FRACTAL GEOMETRY FOR PRE-NEOPLASIC CERVICAL EPITHELIAL CELLS. rev.udcaactual.divulg.cient. [online]. 2011, vol.14, n.1, pp.15-22. ISSN 0123-4226.

SUMMARY Fractal geometry allows the mathematical description of autosimilar, sibisemejants and wild objects. Fractal analysis application to cancer has been able to show changes in the fractal measures of tissues and cells associated in some cases to neoplasic evolution. A new diagnostic methodology for pre-neoplasic cells in cervical cytologies was developed, beginning with the digital photographies of 8 cells, 4 healthy cells, -3 superficials and 1 intermediate-, 2 ASCUS and 2 L-SIL, diagnosed according to conventional parameters. Fractal dimensions from three objects, nucleus, cytoplasm without nucleus and totality, were calculated with Box- Counting method, estimating variability and cellular intrinsic mathematical harmony of fractal dimensions. Mathematical differences between healthy and L-SIL cells were found, making evident that ASCUS cells can have both healthy or L-SIL associated values. This new methodology constitutes the first objective and quantitative evaluation of preventive diagnosis and clinical application for pre-neoplasic cervical injuries. Making quantitatively evident the degree of evolution from normal cells to L-SIL, this methodology gives a solution to diagnostic indetermination of ASCUS cells.

Keywords : Uterine cervix cancer; fractal geometry; cytology.

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