Abstract

ZAMBRANO URBANO, Jose Leonel; OCAMPO CHAPARRO, José Mauricio; LERMA FLORES, Eduardo  and  CASANOVA, María Eugenia. Serotonin syndrome as an infrequent adverse reaction to synergy between Linezolid and Fentanyl: case presentation. Medicas UIS [online]. 2020, vol.33, n.3, pp.59-66.  Epub Oct 30, 2020. ISSN 0121-0319.  https://doi.org/10.18273/revmed.v33n3-2020007.

Serotonin syndrome is a life-threatening condition caused by medications that affect serotonin metabolism or that act as direct agonists for serotonin receptor or a combination of both. The syndrome gives rise to a variety of mental, autonomic, and neuromuscular manifestations, which can range from mild to life-threatening. We report a clinical case of a patient who developed this syndrome due to the co-administration and synergism of linezolid and fentanyl, with a wide variety of clinical characteristics, from the most subtle, such as high blood pressure levels difficult to manage while under the effect of sedoanalgesia, to the most florid manifestations of the syndrome after 48 hours of its suspension. The association of these drugs represents a poorly reported etiology that may favor the appearance of the syndrome, while the use of benzodiazepines may mask the condition, making its diagnosis difficult. MÉD.UIS.2020;33(3): 59-66

Keywords : Serotonin syndrome; Linezolid; Fentanyl.

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