Abstract

PARRADO, Ralph. Metronidazole use during the first trimester of pregnancy: a review. Rev Colomb Obstet Ginecol [online]. 2003, vol.54, n.1, pp.43-46. ISSN 0034-7434.

Background: Metronidazole is used extensively in the obstetric patient due to the obstetric complications associated to bacterial vaginosis and trichomoniasis. However, physicians and patients alike hesitate to use metronidazole, especially during the first months of pregnancy fearing possible teratogenic effects. Objective: To evaluate teratogenic risk of metronidazole during the first trimester of pregnancy. Method: Review of medical literature on metronidazole use during the first trimester of pregnancy and its teratogenic effects. Conclusion: Metronidazole exposure during the first trimester of pregnancy does not appear to increase the risk of overall birth defect occurrence.

Keywords : metronidazole; pregnancy; teratogenicity.

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