Services on Demand
Journal
Article
Indicators
- Cited by SciELO
- Access statistics
Related links
- Cited by Google
- Similars in SciELO
- Similars in Google
Share
Revista Colombiana de Obstetricia y Ginecología
Print version ISSN 0034-7434On-line version ISSN 2463-0225
Abstract
RAMIREZ-CHEYNE, Julián; PACHAJOA, Harry; ISAZA, Carolina and SALDARRIAGA, Wilmar. Is aglossia adactylia syndrome and prenatal exposure to misoprostol a causal or casual relationship?: A case report. Rev Colomb Obstet Ginecol [online]. 2008, vol.59, n.3, pp.248-252. ISSN 0034-7434.
Introduction and objective: thea glossiaa dactylia syndrome is an infrequently occurring congenital polymalformative syndrome, having nuclear aetiology and inheritance pattern. A bibliographical search was carried out, orientated towards the association between the prenatal exposure to misoprostol and congenital malformations. A case of this syndrome is presented which was associated with prenatal exposure to misoprostol during the 10th week of gestation; such association has not been established in the literature reviewed. Presentation of the case: a newborn having phenotypical aglossia adactylia syndrome characteristics, the son of a 17-year-old mother having antecedents of having used a 400 microgram oral dose and a 200 microgram vaginal dose of misoprostol at 10 weeks gestation with the aim of interrupting her pregnancy. Discussion: misoprostol is a synthetic prostaglandin E1 analogue; it has been associated with increased risk of Moebius sequence occurring, arthrogryposis, aglossia adactylia syndrome and terminal and cross-sectional extremity defects in mothers who have used this drug during their first gestation trimester.
Keywords : congenital defect; misoprostol; pregnancy.