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Acta Neurológica Colombiana
Print version ISSN 0120-8748On-line version ISSN 2422-4022
Abstract
MALOOF ROJAS, Geraldin; ZAPATA GARCIA, Juan Pablo and BECERRA-HERNANDEZ, Lina Vanessa. Guillain-Barré syndrome post-SARS-CoV-2 infection and post-vaccination against COVID-19: a systematic review of cases. Acta Neurol Colomb. [online]. 2022, vol.38, n.3, pp.154-171. Epub Oct 23, 2022. ISSN 0120-8748. https://doi.org/10.22379/24224022421.
INTRODUCTION:
Guillain-Barre syndrome (GBS) has recently been associated with SARS-CoV-2 infection and vaccination. The objective of this review is to describe the sociodemographic data and the clinical presentation of GBS associated with infection and vaccination against COVID-19.
MATERIALS AND METHODS:
A systematic search was performed in the Medline, Embase and LILACS databases. Case reports published in 2021-2022 are included. From the selected articles, age, sex, comorbidi-ties, vaccine brand, symptom onset time, clinical manifestations, diagnostic method, treatment received and outcome were extracted.
RESULTS:
93 articles were selected, reporting a total of 131 cases: 82 associated with SARS-CoV-2 infection and 49 associated with vaccination against COVID-19. The most affected population was the male sex and was between 31 and 65 years old. The main manifestations described were: limb paresis, compromised sensitivity, areflexia, compromised cranial nerves.
DISCUSSION:
The clinical picture of GBS presented characteristics similar to the classic presentation. Dys-autonomia and respiratory failure are the main fatal complications of this entity.
CONCLUSION:
GBS can present in a postinfectious, parainfectious manner. It should be suspected when consulting for a clinical picture of demyelinating neuropathy with a history of immunization or concomitant symptoms suggestive of COVID-19. More studies are needed to establish an association between the virus and GBS.
Keywords : COVID-19; Guillain-Barré syndrome; Polyneuropathies; SARS-CoV-2; Vaccines. (MeSH).