Abstract

HINCAPIE-ROJAS, Daniel Fernando et al. Mesoporous Silica Nanoparticles obtention, functionalization and biomedical applications: a review. Dyna rev.fac.nac.minas [online]. 2020, vol.87, n.215, pp.239-253.  Epub Jan 15, 2021. ISSN 0012-7353.  https://doi.org/10.15446/dyna.v87n215.88586.

Recently, inorganic nanoparticles have been extensively researched as therapeutic agents in the biomedical fields due to their exceptionally physical, chemical and biological properties, their easy surface functionalization, their loading capacity also their excellent biocompatibility. The growing increase in research focused on inorganic nanoparticles, especially silica particles, has led to an understanding of their behaviour in biomedical applications because they are a biomaterial with high mechanical strength, bioactivity and improved resorbability. In this article, we review the recent studies based on Silica Mesoporosa (MSN) nanoparticles whose main focus is on different methods of synthesis, functionalization, surface coating and some biomedical applications such as controlled drug delivery and diagnostic imaging. Finally, the impacts of chemical modifications to the surface of nanoparticles are presented in terms of their biocompatibility and the various biomedical applications due to their outstanding characteristics.

Keywords : mesoporous silica nanoparticles; biocompatibility; drug delivery; antibacterial; antincancer; diagnostic imaging.

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