Abstract

BAENA, Yolima; DALLOS, Leidy J.; MANZO, Rubén H.  and  PONCE D'LEON, Luisa F.. Standardization of Franz cells to evaluate drugs release from drug-polyelectrolyte complexes. Rev. colomb. cienc. quim. farm. [online]. 2011, vol.40, n.2, pp.174-188. ISSN 0034-7418.

This paper presents the studies carried out about the standardization of the operational conditions of some Franz Cells; this system allows evaluating the drug release, among others. To this purpose, two Eudragit E- benzoic acid complexes were selected and characterized, as models due to their solubility. After that, the outstanding operational variables were established and evaluated at different levels. The delivery profiles analysis applying the Korsmeyer-Peppas model showed that the release mechanism of benzoic acid was Fick diffusion, in some cases. The operational conditions: benzoic concentration in the complex dispersion in the donor compartment, 0,07%; agitation speed, 400 rpm; volume (1 mL) and frequency sampling according to specific scheme, were determined. The delivery assay reproducibility was demonstrated in the established operational conditions by statistically analysis (ANOVA).

Keywords : Franz cells; standardization; complexes; benzoic acid; delivery.

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