Abstract

CASTILLO, Julián Sánchez  and  GUTIERREZ, José Julián López. Levothyroxine treatment failure in the management of hypothyroidism in a health institution in Bogotá, D. C. An analytical study of prevalence. Rev. colomb. cienc. quim. farm. [online]. 2015, vol.44, n.1, pp.16-33. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v44n1.54234.

Objective: Levothyroxine therapeutic failure has implications for patients, health professionals and institutions, caused in part by pharmacokinetics, interactions and special conditions of taking the drug, the main objective of the study was to determine the association of these causes. Methodology: Prevalence analytical study to assess the main causes of treatment failure with levothyroxine in the treatment of hypothyroidism. Results: The treatment failure occurred in 33.8% of the study population. The protective factors are consumption over 60 months OR 0.74 (0.56-0.97), stable socioeconomic status OR 0.66 (0.58 to 0.75), always take it with water OR 0.69 (0.55 to 0.86) and the drug formulated always OR 0.66 (0.58-.75). The only risk factor is a history irritable colon OR 1.53 (1.34 to 1.73). Logistic regression did not show any statistically significant variable associated possibly to sample size. Conclusions: We identified factors that favor therapeutic failure (risk factors), and others that reduce the likelihood of presenting (protective factors) and the emphasis on them can be a different approach to the problem probably occurs in greater proportion to that reported by this study, and on which there is no effective solution for the lack of research on the topic

Keywords : therapeutic failure; levothyroxine, hypothyroidism; risk factors.

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