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Revista Colombiana de Ciencias Químico - Farmacéuticas
Print version ISSN 0034-7418On-line version ISSN 1909-6356
Abstract
TKACH, Volodymyr V. et al. The theoretical description for olanzapine electrochemical determination, assisted by the cobalt (III) oxyhydroxide composite with a squaraine dye. Rev. colomb. cienc. quim. farm. [online]. 2021, vol.50, n.3, pp.764-775. Epub Dec 20, 2023. ISSN 0034-7418. https://doi.org/10.15446/rcciquifa.v50n3.100864.
Introduction:
olanzapine is one of the most used antipsychotic drugs in the world. Although it is efficient, it may be toxic in excess. Therefore, in this work the possibility of olanzapine electrochemical determination over an electrode, modified by the cobalt (III) oxyhydroxide in pair with its dioxide in a composite with squaraine dye.
Methods:
the trivariant correspondent mathematical model includes two scenarios of the drug oxidation, possible for the case, including the indirect electropolymerization of the condensed benzodiazepine molecule, like also its oxidation by sulfur atom. This model has been developed and analyzed by means of stability theory and bifurcation analysis.
Results and discussion:
the analysis of the model has shown that the mechanism hybridity of the electroanalytical process, alongside with the formation and decomposition of ionic compounds during its realization, augments the possibility for the oscillatory behavior realization, relatively to the simplest and commonest case. Nevertheless, the oscillatory instability is realized in parameter values far beyond the detection limit. On the other hand, the stable steady-state is easy to obtain and maintain, indicating an efficient electroanalytical process, controlled by the analyte diffusion.
Conclusions:
the electroanalytical process is efficient. The cobalt compound is acting as an active substance, and the dye is the mediator.
Keywords : olanzapine; electrochemical sensors; cobalt oxyhydroxide; squaraine dyes; electrochemical oscillations; stable steady-state.