Services on Demand
Journal
Article
English (pdf)
Article in xml format
Article references
Automatic translation
Send this article by e-mailIndicators
Cited by SciELO 
Access statistics
Related links
Cited by Google 
Similars in
SciELO 
Similars in Google
Share
Permalink
Revista Colombiana de Ciencias Químico - Farmacéuticas
Print version ISSN 0034-7418On-line version ISSN 1909-6356
Abstract
VARGAS-SANTANA, Martha Sofía et al. Extended Hildebrand solubility approach and Yalkowsky-Roseman mode l for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures. Rev. colomb. cienc. quim. farm. [online]. 2021, vol.50, n.3, pp.812-836. Epub Dec 18, 2023. ISSN 0034-7418. https://doi.org/10.15446/rcciquifa.v50n3.100240.
Aim:
extended Hildebrand Solubility Approach (EHSA) and Yalkowsky Roseman (YR) were applied to evaluate the solubility of sulfadiazine, and sulfamethazine in ethylene glycol + water mixtures.
Methodology:
reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations.
Results:
a good predictive character of EHSA (with mean deviations lower than 3.0%) were found by using regular polynomials in order two correlating the inter-action parameter W with the Hildebrand solubility parameter of solvent mixtures without drug; however, the results obtained from YR model show relatively high deviations greater than 50%.
Keywords : Sulfadiazine; sulfamethazine; extended Hildebrand model; Yalkowsky-Roseman; solubility; cosolvent mixtures.
