Abstract

GARCIA-VALENCIA, Jenny et al. Efecto de la agregación familiar en la caracterización clínica del trastorno afectivo bipolar tipo I Variables en pacientes de población antioqueña. rev.colomb.psiquiatr. [online]. 2003, vol.32, n.2, pp.145-160. ISSN 0034-7450.

Objective: To clinically characterize patients with Bipolar Mood Disorder I (BD I), taking into account the presence or not of familial aggregation. Methods: This is an observational cross sectional study. The family trees of the patients with BD I were extended, possibly affected relatives were identified, and the Diagnostic Interview for Genetic Studies (DIGS) was performed by psychiatrists who did not know the family background of the subjects, in order to confirm the diagnosis and recollect clinical data. Results: The clinical characteristics of BD I were described in this group of patients. In the correspondence analysis various symptomatic groups were identified. An association between family aggregation and worse outcome of the depressive episodes, together with worse interepisode functioning was identified. Conclusions: (1) The clinical characteristics and symptomatic groups found are similar to those described in the literature. (2) Patients with family aggregation seem to have a worse outcome disorder. (3) Multiple correspondence analysis is a very useful tool for the study of psychiatric phenomenology.

Keywords : Bipolar disorder; family aggregation; disease attributes; genetics.

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