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Revista Colombiana de Ciencias Pecuarias
Print version ISSN 0120-0690
Abstract
ZEPEDA BATISTA, José L; CARRILLO DIAZ, María I and SAAVEDRA JIMENEZ, Luis A. Sources of bias in genetic association studies in cattle: A review. Rev Colom Cienc Pecua [online]. 2018, vol.31, n.4, pp.256-266. ISSN 0120-0690. https://doi.org/10.17533/udea.rccp.v31n4a02.
Background:
Genetic association studies have been increasingly used in cattle breeding programs. However, inconsistent results -such as positive, negative, or absence of association- across studies restrain reproducibility and proper implementation, propitiating the occurrence of bias.
Objective:
To identify and classify potential sources of bias and determine possible strategies to avoid it in genetic association studies in cattle.
Source of bias in genetic association studies:
Genetic and genomic sources of bias include effects associated with the gene loci governing expression. Sampling-related and statistical biases are related with factors such as stratification and database size.
Strategies to correct bias in genetic association studies:
Correction strategies differ in nature. Genetic and genomic strategies are based on determining the appropriate approach to obtain and report the genetic information. Sampling-related and statistical strategies are based on grouping individuals with certain traits that lead to a reduction in heterogeneity.
Conclusion:
It is necessary to consider the methodology used in previous studies to establish a hierarchy of sources of bias and facilitate decisions on the use of tools to reduce inconsistencies in the results of future studies.
Keywords : association estimates; genetic bias; genetic improvement; sampling-related bias; statistical bias..