Abstract

ANGULO-CORNEJO, Jorge Reinaldo  and  TOVAR-TABOADA, Carlo Felipe. Synthesis of thioureas with structural isoniazid and niazid: test against Gram + and Gram - bacteria. Rev.Colomb.Quim. [online]. 2023, vol.52, n.1, pp.49-54.  Epub Mar 06, 2024. ISSN 0120-2804.  https://doi.org/10.15446/rev.colomb.quim.v52n1.108362.

The compounds N-(2-nicotinoylhydra-zine-1-carbonothioyl)benzamide (H3L1) and its isomer N-(2-isonicotinoylhydra-zine-1-carbonothioyl)benzamide (H3L2) type N, S, O donors, by reaction of benzoyl isothiocyanate with nicotinic hydrazide and isoniazid respectively were synthesized. The H3L1 and H3L2 compounds were characterized by 1H-NMR, 13C-NMR, FT-IR and elemental analysis. Computational analysis using the Fukui functions were performed to determine the reasons why the 1,2,4-triazoles were not formed. Preliminary tests of the synthesized compounds were carried out against Staphylo-coccus aureus (Gram+) and Escherichia coli (Gram-), having demonstrated significant activity against such bacteria.

Keywords : N, S, O donor compound; ben-zoylthioureas; DFT; Fukui functions.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )