Abstract

NINO DE MEJIA, María Claudia; CHAVES, Alexandra  and  SALAZAR, Claudia Jimena. Cambios hemodinámicos durante la inducción anestésica con tiopental versus propofol en pacientes asa I y II. Rev. colomb. anestesiol. [online]. 2007, vol.35, n.1, pp.53-58. ISSN 0120-3347.

Objective: To determine hemodynamic changes (heart rate, systolic, diastolic and mean arterial pressure) during anesthetic induction phase in patients ASA I and II scheduled for elective surgery, when using Sodium Thiopental versus Propofol at University Hospital Fundación Santa Fe de Bogotá. As a secondary objective, the proportion of patient requiring vasopressors and intravenous fluids to overcome the hypotension caused by these induction drugs during the first 30 minutes of anesthesia will be determined. Methods: randomized controlled clinical trial with secuential sampling by convenience. Patients where divided in two groups, the first of them received Sodium Thiopental (3-5mg/kg) and the second, Propofol (1-2 mg/kg). In order to avoid bias, the induction technique was standarized. hemodynamic data was captured (heart rate, systolic, diastolic and mean arterial pressure), a mean was calculated from the first three meassurements of each variable previous to anesthetic induction and previous to the administration of any medication, which was named T0. The next measurements where done 3 minutes after one dose of neuromuscular relaxant before intubation (T1), and 3(T2), 5(T3), 10(T4), and 15 minutes (T5) after intubation. Vasopressor and intravenous fluid requirements where quantifyed. Results: There where no statistically significant differences between hemodynamic parameters, use of vasopressors (7% versus 8%) or intravenous fluids between groups. Conclusions: There is no statistical or clinical difference in the outcomes studied between the use of Sodium Thiopental versus Propofol for anesthetic induction in patients ASA I or II.

Keywords : Propofol; Thiopental; Hemodynamic changes; Arterial blood; pressure, Heart rate.

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