Abstract

NAVARRO, J. Ricardo; BARRAGAN, Gabriel; RINCON, David A  and  ESLAVA, Javier H. Analgesia preventiva en mujeres programadas para esterilización definitiva con electrofulguración de trompas uterinas por laparoscopia. Experimento clínico controlado, aleatorizado, con doble enmascaramiento. Rev. colomb. anestesiol. [online]. 2008, vol.36, n.1, pp.25-32. ISSN 0120-3347.

Background: The pre-emptive analgesia keeps being a source of discussion and discord between the spe-cialists in the pain management. There are contradictory results, even in meta-analysis, about effectiveness of preemptive analgesia with ketamine. Objective: To evaluate effectiveness of ketamine as preemptive analgesia in women under laparoscopic electrofulguration of Falopio tubes, in control of postoperative pain, compared with ketamine administered in a non preemptive way. material and methods: 130 women who wanted a defnitive contraceptive method as laparoscopic tubal ligation were included with the diagnosis of satisfed parity, from the Clínica Piloto de Profamilia, in Bogotá (Colombia), between december 2007 and january o2008. They were randomly assigned in two groups: 71 received preemptive ketamine (before initiating the surgical procedure, dose of 0,25 mg/kg) and the other 59 patients received ketamine, the same doses, at the end of the procedure. Both, administration of ketamine and evaluation of patients outcomes, were made in blinded form. Results: Patients were similar at the start of the study. The level of pain measured with a visual analog scale (VAS) was similar for both groups, there was a higher proportion of patients with pain in the preemp-tive ketamine group to the minute 15 (29.7% vs 6.8%) Ketamine non preemptive group, felt more nauseous (25% vs. 10% and seasickness (46% vs 37%), this was not signifcative (p>0.05)). Conclusions: The preemptive ketamine wasn't different in effectiveness to ketamine administered in non preemptive way for the relief of postoperative pain.

Keywords : Preemptive Analgesia; Ketamine; Laparoscopic Tubal Ligation.

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