Abstract

ARANGO, Eliana; ALVAREZ, Tania; CARMONA, Jaime  and  BLAIR, Silvia. Gametocyte levels in response to differing malaria treatments in two municipalities of Colombia. Biomédica [online]. 2004, vol.24, n.1, pp.79-88. ISSN 0120-4157.

Plasmodium falciparum gametocyte levels are influenced by level of regional endemicity, the antimalarial treatment, and the therapeutic response of patients. Few previous studies have related these factors in Colombia. Here, gametocytaemia was evaluated with respect to two treatment schemes (sulfadoxine/pyrimethamine and sulfadoxine/pyrimethamine plus chloroquine), the patient response (adequate or failure), and the locality (two areas of varying case frequency). One hundred forty-eight residents of Turbo and Zaragoza (Antioquia), all with uncomplicated malaria, were evaluated. The gametocytaemia and the rates of clinical malaria at the beginning of treatment were greater in Turbo than in Zaragoza. No statiscally significant differences in the gametocytaemia by treatment schemes or therapeutic responses were noted, although the patients who received SP had more gametocytes than those treated with SP+CQ. Gametocytaemia was not correlated with asexual parasitemia or sex and age of patient. The difference in the level of gametocytaemia between Turbo and Zaragoza appears to be influenced by the time elapsed between the appearance of symptoms and the beginning of treatment.

Keywords : gametocytaemia; P. falciparum; Turbo; Zaragoza; chloroquine; ulfadoxinepyrimethamine; therapeutic.

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