SciELO - Scientific Electronic Library Online

 
vol.43 issue1Liver abscess due to Granulicatella adiacens in an immunocompetent patient: Case reportPulmonary and central nervous system nocardiosis: Alcoholism as an immunocompromising factor author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Biomédica

Print version ISSN 0120-4157On-line version ISSN 2590-7379

Abstract

PEREZ, María Alejandra et al. Infection due to Aspergillus flavus and Rhizopus oryzae complex in a patient with diabetes mellitus. Biomed. [online]. 2023, vol.43, n.1, pp.27-36.  Epub Mar 30, 2023. ISSN 0120-4157.  https://doi.org/10.7705/biomedica.6358.

Fungal sinusitis is a pathology that can occur in patients with diabetes mellitus and be associated with a hyperglycemic crisis. It is an aggressive entity with local complications that include involvement of the orbit or the central nervous system, and vascular involvement. Despite surgical and antifungal treatment, mortality raises up to 75%. We report the case of a female patient with a diagnosis of diabetic ketoacidosis and signs of unilateral ophthalmoplegia, which led to the study with magnetic resonance imaging of the central nervous system, finding signs of sinusitis, meningitis, and cerebritis. Initial microbiological studies were negative, and biomarkers such as serum galactomannan and Cryptococcus antigen were also negative. After surgical management and the identification of Aspergillus flavus and Rhizopus spp. in sinus tissue, the patient received treatment with posaconazole and after two months of follow-up she presented clinical improvement. Dual fungal infection and infection by A. flavus are uncommon and clinically relevant entities, with no cases previously reported in our country, therefore this corresponds to a case of clinical interest.

Keywords : Aspergillus flavus; Rhizopus oryzae; mucormycosis; aspergillosis; invasive fungal infections; sinusitis; diabetes mellitus.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )