Abstract

ALCAZAR ARZUZA, Jéssica Paola; BAYONA ARCINIEGAS, Andrea Julieth; DE LOS REYES, Lina María  and  TURNER, Liliana Francis. Behavioral Evaluation of hMSC-GFP+ Transplantation in an Hemiparkinson Experimental Model in Wistar Rat. Acta biol.Colomb. [online]. 2017, vol.22, n.2, pp.127-136. ISSN 0120-548X.  https://doi.org/10.15446/abc.v22n2.59703.

ABSTRACT The effect of hMSCs-GFP+ transplantation was evaluated in an experimental model of Parkinson's disease (PD) in 27 Wistar rats, or in three experimental groups: control (CON n=7), injured (LES n = 10) and transplanted (LES+T n = 10). In order to evaluate the influence of the transplantation on the motor behavior, one month after the injury, rotation behavior induced by apomorphine, neurological test, transversal bar and SNpc cells positive to TH were developed. Using the Anova test, there was a decrease in the number of turns in transplanted animals (p=0,005) as well as in the neurological test (p=0,0004) and in the transverse bar that lead to this group in an intermediate position regarding LES and CON groups. There is a possible recovery of the transplantation-mediated nigroestriatal pathway of hMSC-GFP +.

Keywords : cell Therapy; mesenchymal stem cells; motor impairment; Parkinson disease; Wistar rat.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )