Abstract

CRUZ QUINTANA, Sandra et al. Genome of Candida albicans and drug resistance. Salud, Barranquilla [online]. 2017, vol.33, n.3, pp.438-450. ISSN 0120-5552.

Candida albicans is an important fungal pathogen in humans both for its clinical importance and its use as an experimental model for scientific research. Understanding the biology of this pathogen is an important requirement for the identification of new drug targets for antifungal therapy. In this review, we propose to delve into the characteristics of the genome of Candida albicans, its relation to virulence and how it influences resistance to antifungal drugs, allowing us to understand the mechanisms by which it exerts its pathogenic action and to develop other approaches in the Search for new antifungals. The review was carried out through the HINARI, SciELO and MEDLINE search engines and platforms. We reviewed 40 Web of Science impact journals related to the topic. The descriptors employed were: "genome of Candida albicans", "drug resistance genes", "dimorphism", "virulence" and the combination between them and their equivalents in Spanish. Analysis of fungal genomes makes it possible to predict the role of genes with therapeutic potential, with sequencing of the genome of Candida albicans has increased information on the function of genes, among which stand out possible pharmacological targets-specific virulence. The study of the genome of Candida albicans is essential for the future design of safe diagnostic protocols, as well as finding new antifungal targets to formulate more effective therapies.

Keywords : biofilm; drugs; genome; genes; molecular epidemiology; yeast.

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