Abstract

ZARATE PENATA, Eloina  and  MARRUGO CANO, Javier. NF-kB inhibitors from diet and their role in allergic diseases. Salud, Barranquilla [online]. 2017, vol.33, n.3, pp.464-476. ISSN 0120-5552.

The NF-kB plays a central role as a regulator of the inflammatory and immune responses. It is found in inactive form in the cytoplasm of cells. After its activation, the NF-kB dissociates from an inhibitory protein and translocate to the nucleus where it participates in the transcription of genes such as inflammatory cytokines, adhesion molecules, immunoglobulins and various receptors on immune cells, among others. This transcription factor has a group of physiological and non-physiological inhibitors. Among the non-physiological, those present in the diet such as carotenoids and polyphenols reduce their activity as a transcriptional inducer. Epidemiological studies have shown that consumption of fruits and vegetables protect against development of allergies. It has been postulated that this protective effect is due to polyphenol and carotenoids present in those foods. These compounds act at various levels of the allergic immune response. Inhibiting Th2 cytokines, inflammatory cell infiltration into tissues, IgE synthesis and the release of pharmacological mediators among others. This is due to their effect on phosphorylation, ubiquitination and degradation of various proteins involved in the processes of inhibition and/or activation of NF-kB.

In this review, we analyze molecular aspects of NF-kB and described inhibitors present in the diet, such as polyphenols and carotenoids, their role in allergic inflammatory process and the development of allergic diseases.

Keywords : NF-kB; inhibitor; diet; allergies; polyphenols; carotenoids.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )