Services on Demand
Journal
Article
Indicators
- Cited by SciELO
- Access statistics
Related links
- Cited by Google
- Similars in SciELO
- Similars in Google
Share
Acta Neurológica Colombiana
Print version ISSN 0120-8748On-line version ISSN 2422-4022
Abstract
GONZALEZ-MANRIQUE, Guillermo et al. Vitamin D levels in patients receiving anticonvulsant treatment for epilepsy in an outpatient clinic in Colombia. Acta Neurol Colomb. [online]. 2020, vol.36, n.2, pp.56-62. ISSN 0120-8748. https://doi.org/10.22379/24224022279.
INTRODUCTION:
Vitamin D acts in many tissues and different physiological processes. The objective was to determine vitamin D levels in patients with epilepsy treated with anticonvulsants.
MATERIALS AND METHOD:
Observational, descriptive, cross-section study in consecutive patients with epilepsy who attended the Neurology outpatient service of a university hospital in Neiva, Colombia, between March and October 31, 2018. We obtained serum levels of vitamin D, parathormone, albumin and calcium.
RESULTS:
There were 90 patients with a median age of 36.5 (range 18-81 years), 46 (51.1%) had low levels of vitamin D (38.8% in the range of insufficiency and 12.2% with deficiency). Females had more insufficient and deficient levels of vitamin D; not exercising was associated with insufficient levels of vitamin D, daily exposure to the sun under 15 minutes and not walking, with deficient levels of vitamin D. Vitamin D deficiency was associated with an increase in parathyroid hormone levels, median 103.9 pg / ml (range 30.7 - 182.9 pg / ml, P <0.01). No difference was found between vitamin D levels and the use of monotherapy, polytherapy, or the use of enzyme-inducing drugs.
CONCLUSIONS:
In epileptic patients with anticonvulsants it is common to find insufficient / deficient levels of vitamin D although we found no association with the use of monotherapy, polytherapy or hepatic enzyme inducers.
Keywords : antiepileptic drugs; deficiency; epilepsy; vitamin D (MeSH).