Abstract

GALLEGO, Carolina  and  VELEZ, Luis Fernando. An approach to "Pemphigus" from dentistry. CES odontol. [online]. 2013, vol.26, n.2, pp.107-117. ISSN 0120-971X.

The approximation to Pemphigus-like lesions that occur in the oral cavity are based on clinical appearance, systemic manifestations, diagnostic criteria, and pathophysiology. This is described as a blister caused by the separation between the desmosomal junctions due to the presence of autoantibodies against adhesion proteins, the desmogleins. Differential diagnosis is pemphigoid and etiology of hereditary or external causes such as ultraviolet radiation, diet, pesticides, drugs, among others. The characteristic presentation feature is a blister with serous fluid which manifests as mucosal sites and skin. It is classified into three main varieties, the vulgar, the foliaceus and paraneoplastic. Its diagnosis is given by clinical appearance and laboratory tests (biopsy, etc.). Treatment includes the use of topical and systemic corticosteroids, starting with high doses and subsequently with low maintenance stages. Many improve with treatment, but some may lead to serious complications, which depending on the patient's immune response.

Keywords : Pemphigus; Descamative gingivitis; Desmoglein; Autoantibodies; Corticosteroids.

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