Abstract

REYES M, Gustavo Adolfo; CARVAJAL P, Germán David; TAPIAS M, Mónica Lorena  and  SABBAGH S, Luis Carlos. Hepatotoxicity due to Isoniazide in a Patient with Crohn’s Disease: Case Report and Literature Review. Rev Col Gastroenterol [online]. 2016, vol.31, n.4, pp.438-442. ISSN 0120-9957.

Isoniazid is used for treatment or prophylaxis of tuberculosis but may be associated with adverse hepatic reactions. Clinically manifest hepatitis occurs in 0.5%-1% of patients who receive isoniazid as monotherapy. This article describes the case of a patient with Crohn’s disease who experienced severe hepatotoxicity due to isoniazid. It also reviews the literature.

Keywords : Isoniazid; hepatotoxicity; DILI (idiosyncratic drug-induced liver injury); Crohn’s disease.

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