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Medicas UIS
Print version ISSN 0121-0319
Abstract
LOPEZ-GARRIDO, Esteban et al. Umbilical cord blood serum procalcitonin as predictor of early onset sepsis in premature infants in Tamaulipas México, 2016. Preliminary results. Medicas UIS [online]. 2018, vol.31, n.1, pp.23-30. ISSN 0121-0319. https://doi.org/10.18273/revmed.v31n1-2018003.
Introduction:
Sepsis is a cause of high mortality in the premature, it affects up to 19 of 1000 in children under 1000 g and its manifestation may be nonspecific. Decision-making on the use of antibiotics is not always easy, so it is worth having an fast, cheap and effective predictor of early onset sepsis.
Objective:
To determine the use of serum procalcitonin umbilical cord as a predictor of early onset sepsis in preterm infants.
Materials and methods:
Longitudinal descriptive study from june to november 2016 was made. 22 preterm infants (<37 weeks of gestation) were included, with or without risk factors for infection. Neonates with malformations or suspicion of metabolic disease were excluded. A blood sample was taken from the umbilical artery for procalcitonin and blood culture at birth, subsequently they were assessed from birth to 72 hours of life for sepsis data.
Results:
Twelve developed early onset sepsis and ten did not. The mean procalcitonin of umbilical cord in the sepsis group was 0.68 ng/ml versus 0.13 ng/ml in the group without sepsis, p=0.025. In the analysis under the ROC curve area for procalcitonin was 0.75. The cut value of umbilical cord procalciton was 0.14 ng/ml as a predictor of early sepsis (sensitivity 75%, specificity 70%, positive predictive value 75%, negative predictive value 70%).
Conclusions:
Procalcitonin of umbilical cord at birth may be a useful parameter as a marker of early onset sepsis in the premature, however these results must be validated with a larger sample size. MÉD.UIS. 2018;31(1):23-30.
Keywords : Procalcitonin; Umbilical Cord; Neonatal Sepsis; Infant; Premature.