Abstract

FORERO-ARGUELLO, Hámilton et al. Characterization and pathophysiology of sars-cov-2, actual literature review. Medicas UIS [online]. 2021, vol.34, n.2, pp.61-75.  Epub Sep 28, 2021. ISSN 0121-0319.  https://doi.org/10.18273/revmed.v34n2-2021006.

Coronavirus disease 2019 (COVID-19) is caused by a new betacoronavirus named as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). On June 22nd, 2021, the number of confirmed cases worldwide exceeded 178 million, resulting in more than 3 million deaths. The pathophysiology of COVID-19 from the infection of SARS-CoV-2 is not entirely elucidated. This review presents the findings after the research in the scientific literature carried out in the PubMed database between October 2020 and April 2021, in which 71 articles were included, with the aim of a complete, detailed and updated pathophysiological review of SARS-CoV-2, addressing issues such as the characterization and life cycle of the virus, the transmission mechanism, viral kinetics and immune response, along with the pathophysiological dynamics of the infection. MÉD.UIS.2021;34(2): 61-75.

Keywords : COVID-19; SARS-CoV-2; Pathogenicity; Viral proteins; Pathophysiology; Immune response.

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