Abstract

RAMIREZ RAMIREZ, Carolina. A view from the molecular biology toward an impairment commonly found in the physiotherapist's practice: muscular atrophy. Rev. Univ. Ind. Santander. Salud [online]. 2012, vol.44, n.3, pp.31-39. ISSN 0121-0807.

Muscle atrophy is a common impairment in patients attended by physical therapists; to understand the molecular pathways that regulate this condition is important to a whole vision of patient condition. There are three pathways involved in the muscular atrophy regulation: the calpains, lysosomal and the ubiquitin proteosome pathway. These pathways carry out the bulk of muscle protein degradation, regardless its etiology. Atrogina-1 and MuRF1, two enzimes belonging to the ubiquitin proteosome pathway, increase significantly in muscular atrophy in part due to enhanced expression of tumoral necrosis factor-alpha. The understanding of molecular mechanisms involved in the muscular atrophy regulation is important to the Physical Therapist because it helps to get deeper knowledge about the clinical condition treated, and propose investigation questions that could be solved through molecular biology applications. Salud UIS 2012; 44 (3): 31-39

Keywords : muscular atrophy; rehabilitation; molecular biology.

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