Abstract

BLANCO, MARGARITA INES et al. TRANSPLANT AUTOLOGOUS "ENHANCED" STEM CELLS CD34+ BONE MARROW IN PATIENTS WITH REFRACTORY ANGINA: ESTUDO PILOTO. rev.fac.med [online]. 2016, vol.24, n.1, pp.46-58. ISSN 0121-5256.  https://doi.org/10.18359/rmed.2331.

Objective: To evaluate the efficacy of 6 months of autologous CD34+ stem cells in bone marrow "enhanced" by ischemic preconditioning in patients with refractory angina. Methods: A pilot study with 14 patients with refractory angina, with a functional class greater than or equal to III clinical (NYHA and CCS), of the Department of Cardiology of the Central Military Hospital. They were selected by convenience 14 patients who were randomly assigned to two groups, the first (intervention) with autologous stem cells CD34+ bone marrow powered by ischemic preconditioning, intravenously more conventional medical treatment, and the second (control) with conventional medical treatment. Baseline measurements were performed and six months' threshold angina/ischemia measured in mets and functional class. Results: Comparing the medians, the change in threshold value angina/ischemia six months later for the intervention group was 3.5 mets vs 0.9 mets for the control group P = 0.013. No inherent complications to treatment were recorded. Conclusions: In this study patients with refractory angina who underwent autologous stem cell transplant of bone marrow CD34+ powered by ischemic preconditioning, showed an improvement in threshold angina and functional class of 6 months.

Keywords : Hematopoietic stem cells; Angina pectoris; Ischemic preconditioning.

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