Abstract

MURILLO, Raúl. Neoantigen vaccines and cancer control: perspectives. rev.colomb.cancerol. [online]. 2020, vol.24, n.4, pp.165-175.  Epub Mar 30, 2021. ISSN 0123-9015.  https://doi.org/10.35509/01239015.195.

Overall survival and quality of life are primary goals of cancer treatment. The recent development of targeted therapies has fostered the concept of personalized treatments, which have been evaluated mainly through tumor-centered outcomes and have focused on low-prevalence tumors and advanced stages. Immunotherapy halts this trend and generates expectation regarding its impact on overall survival and its potential use in a wide range of tumors. As part of immunotherapy, neoantigen vaccines have shown high efficacy and safety due to their affinity with T cells and their high specificity. Based on biological principles, we reviewed their potential impact on the burden of disease given the immunogenicity and prevalence by tumor type, the possible effect on clinical practice due to their combination with other treatment modalities, and the effect on access to treatment, given the process of development and production and the availability of local data.

Keywords : Neoplasms; Neoantigens; Vaccines/terapeutic use; Cancer control.

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