Services on Demand
Journal
Article
Indicators
Cited by SciELO
Access statistics
Related links
Cited by Google
Similars in SciELO
Similars in Google
Share
Revista de Salud Pública
Print version ISSN 0124-0064
Abstract
HOYOS-GIRALDO, Luz S.; RAMOS-ANGULO, Jovanna V. and REYES-CARVAJAL, Ingrid. Cancer risk evaluation in individuals occupationally exposed to organic solvents. Rev. salud pública [online]. 2020, vol.22, n.3, pp.265-279. Epub Oct 10, 2020. ISSN 0124-0064. https://doi.org/10.15446/rsap.v22n3.80224.
Objective
To evaluate the frequency of micronuclei (MNs) and influence of GSTM1 and GSTT1 gene polymorphisms as biomarkers of cancer risk in car painters (n=152) compared to unexposed individuals (n=152).
Methods
Molecular epidemiology study, cross-sectional analysis of gen and environment interaction. The evaluation of MN and genetic polymorphisms was determined by molecular tests in lymphocytes from subjects involved in the study.
Results
It was determined that the frequency of MNs is 1.6 higher in the exposed group compared to the reference group (1.39 ± 0.92 versus 0.87 ± 0.78, p<0.0001). There was no increase in the frequency of MNs associated with the polymorphisms in GSTM1 and GSTT1.
Conclusions
The increase of MNs in car painters serves to alert the increased risk of cancer in this population exposed to organic solvents. These results can be used in Occupational Epidemiological Surveillance Programs, as a prevention strategy and policies to regulate and control the use of solvents at a national level and in other countries with a large informal sector of individuals exposed to these chemicals to reduce the risk of cancer.
Keywords : Solvents; micronuclei; cancer; genetic predisposition to disease (source: MeSH, NLM).