Abstract

OSORIO, José Henry  and  AGUIRRE, César Augusto. RELATIONSHIP BETWEEN THE TRIGLYCERIDES METABOLISM AND ATHEROSCLEROSIS IN FAMILIAL HYPERCHOLESTEROLEMIA. Biosalud [online]. 2013, vol.12, n.1, pp.39-48. ISSN 1657-9550.

Familial hypercholesterolaemia (FH) is a genetic disorder, with the heterozygous form affecting one in 500 deliveries. FH is associated with atherosclerosis due to elevated LDL concentrations but also, triglyceride levels and postprandial hypertriglyceridemia have been reported as possible independent risk factors for atherosclerosis. In the present review article available literature in the data basesinformation from database PubMed as well as historical articles, texts and references cited in public published papers to date were analyzed, searching a possible relationship between triglyceride metabolism in FH and atherosclerosis. The information obtained was organizedPertinent information related with the objectives proposed in the present review was found and analyzed. It was then divided into three sections as follows: triglyceride metabolism, triglyceride metabolism in familiar hypercholesterolaemia, triglycerides in familiar hypercholesterolaemia and atherosclerosis. Among the conclusions iIt was found that can be concluded that high levels of triglycerides are associated to with high risk of early coronary heart disease in FH patients.

Keywords : lipids; atherosclerosis; familial hypercholesterolaemia.

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