Abstract

CASTILLO, Martha  and  OLIVEROS, Ana Lucia. Characterization of molecular alterations of hemoglobin in Afro-Colombians. Nova [online]. 2014, vol.12, n.22, pp.151-156. ISSN 1794-2470.

Objective: Characterize molecular alterations of hemoglobin in Afro-Colombian subjects, ranging in age from 18 to 50 years. Analyses were conducted via complete blood count, peripheral blood smear, C-Reactive Protein, serum Ferritin, Soluble Transferrin Receptor (sTfR) and electrophoresis. Materials and Methods: A total of 56 subjects were analyzed, 10 men and 46 women. Results: Subjects (from the Aguablanca District in the City of Cali) showed alterations in the hemoglobin chain associated with Hemoglobin S, Hemoglobin C and possible thalassemias due to Fetal Hemoglobin and augmented Hemoglobin A2. Additionally, a small incidence of subclinical deficiencies of iron at different stages was also detected.

Keywords : Afro-Colombian; Hemoglobinopathies; iron deficiencies; anemias.

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