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Urología Colombiana
On-line version ISSN 2027-0119
Abstract
SANDOVAL, Juan Manuel et al. Mortality Related to SARS-CoV-2 in Patients with Kidney Transplant from a Center in Northeastern Colombia. Urol. Colomb. [online]. 2022, vol.31, n.4, pp.170-176. Epub June 07, 2024. ISSN 2027-0119. https://doi.org/10.1055/s-0042-1759626.
Objective:
To describe the mortality related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the risk factors associated with disease severity in patients submitted to a kidney transplant from a center in northeastern Colombia.
Materials and Methods:
The present is a descriptive study of a cohort of patients in follow-up care after kidney transplant, with a retrospective search for those who presented SARS-CoV-2 infection between March 2020 and May 2021. Patients with confirmed infection by polymerase chain reaction (PCR), antigens or antibodies tests were included for analysis. We performed a descriptive analysis of the sociodemographic and clinical variables as well as a bivariate analysis to evaluate the possible factors associated with the risk of mortality.
Results:
With a total of 307 individuals in follow-up care, a prevalence of 14.3% (n = 44) of coronavirus disease 2019 (COVID-19) infection was found. The mean age of the sample was of 56 years, with a male predominance. The most frequent immunosuppression regimen was mycophenolate-tacrolimus-prednisone. Among the infected patients, the mortality rate was of 34.1% (15/44), representing 4.8% of the entire study population. More than half of the patients required hemodialysis, and 86.7% required adjustments to the immunosuppression regimen.
Conclusion:
The prevalence of SARS-CoV-2 infection in our transplant group was similar to that reported by other transplant groups in the country and higher than among the non-transplanted population. The preinfection creatinine value, age, and comorbidities were associated with a higher risk of mortality.
Keywords : mortality; kidney transplant; chronic renal insufficiency; coronavirus infections; risk factors.