Abstract

MONTORO, Ernesto et al. Vigilancia de la resistencia de Mycobacterium tuberculosis a las drogas antituberculosas en Cuba, 1995-1998. Biomédica [online]. 2004, vol.24, suppl.1, pp.80-84. ISSN 0120-4157.

Surveillance of resistance of Mycobacterium tuberculosis to anti-TB drugs in Cuba, 1995-1998 Drug-resistance surveillance by means of culture and drug susceptibility test (DST) allows the estimation of the regional and global magnitude of multidrug-resistance (MDR). Two reports on anti-tuberculosis drug resistance by the WHO/IUATLD showed that drug-resistance TB varied widely across regions. Thecurrent study determined the prevalence of drug resistance among new cases and among previously treated cases of tuberculosis in Cuba during the period 1995-1998. Using the proportion method, drug resistance was determined in 1,379 Mycobacterium tuberculosis strains to four front-line anti- tuberculosis drugs (isoniazid, streptomycin, ethambutol and rifampicin). In two separate studies, the overall resistance in new cases was 8.3% and 6.5%, and the MDR was 0.7% and 0%, respectively. The Cuba data demonstrated that Colombia, in comparison, is relatively free of MDR strains, indicating effective tuberculosis control programs in Colombia and the success of the direct observation-treatment strategy that has been in continuous use since 1971

Keywords : resistance; Mycobacterium tuberculosis; Multidrug- resistant.

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